Molecular and genetic studies around the turn of this century have revolutionized the field of
cardiac development. We now know that the primary heart tube, as seen in the early embryo …

In 2014, an extensive review discussing the major steps of cardiac development focusing on
growth, formation of primary and chamber myocardium and the development of the cardiac …

Cardiovascular malformations are the most common type of birth defect and result in
significant mortality worldwide. The etiology for the majority of these anomalies remains …

Congenital heart defects are common in humans, but the underlying basis for these defects
is not well understood. It has been clear that abnormal heart development is at the root of …

Developmental genetics of congenital heart diseases has evolved from analysis of embryo
sections towards molecular genetics of cardiac morphogenesis with a dynamic view of …

Congenital heart disease in humans results from abnormal morphogenesis of the embryonic
cardiovascular system. The characterization of mutations affecting cardiovascular …

Developmental heart disorders are the most common of all human birth defects and occur in
nearly one percent of the population. Survivors of congenital heart malformations are an …

▪ Abstract Recent discoveries have led to a greater appreciation of the diverse mechanisms
that underlie cardiac morphogenesis. Genetic strategies (primarily gene targeting …

Abstract Background Congenital heart diseases (CHDs) are the most common congenital
anomalies with an estimated prevalence of 8 in 1000 live births. CHDs occur as a result of …

Cardiovascular malformations are the most common type of birth defect and result in
significant mortality worldwide. The etiology for the majority of these anomalies remains …