Adenocarcinoma is the most lethal gynecologic tumor and treatment usually consists in
surgery followed by chemotherapy. However, the chemotherapy benefits are eventually …

Paclitaxel is a microtubule inhibitor causing mitotic arrest and is widely used in cancer
chemotherapy. However, its poor water solubility restricts its direct clinical applications. In …

Paclitaxel is one of the most effective chemotherapeutic agents for treating various types of
cancer. However, the clinical application of paclitaxel in cancer treatment is considerably …

Ovarian cancer is the most lethal gynecological cancer of female reproductive system. In
order to improve the survival rate, some modifications on nanoparticles surfaces have been …

Purpose The aim of this study was to test the ability of paclitaxel-loaded poly
(butylcyanoacrylate)(PBCA) nanoparticles to overcome multidrug resistance (MDR) in …

This report is an integrated study to include the molecular simulation, physicochemical
characterization and biological analysis of a paclitaxel-loaded PHBV nanoparticle that …

Paclitaxel (PTX), an antimicrotubular agent used in the treatment of ovarian and breast
cancer, was encapsulated in nanoparticles (NPs) of poly (lactide-co-glycolide)(PLGA) and …

Ovarian carcinoma (OC) is one of the leading causes of death among gynecologic
malignancies all over the world. It is characterized by high mortality rate because of the lack …

The main challenge encountered while treating using Paclitaxel (PTX) is its poor solubility in
aqueous solutions. The cremophor used in the formulation can cause various side effects …

Paclitaxel is one of the best antineoplastic drugs found from nature in the past decades,
which has been found effective against a wide spectrum of cancers including ovarian …