Inhibitor of beta-catenin and TCF (ICAT) is a key protein in the Wnt-β-catenin signaling
pathway. However, its role in acute myeloid leukemia (AML) remains unknown. In this study …

Background Canonical Wnt/β-catenin signaling is frequently dysregulated in acute myeloid
leukemia (AML) and has been implicated in leukemogenesis. γ-catenin was previously …

This study was aimed to quantitatively detect the levels of beta-catenin and cyclin D1 mRNA
in various subgroups of acute myeloid leukemia (AML) and to analyze their potential …

Objective To investigate the expression of beta-catenin in patients with leukemia and
explore its significance in leukemias. Methods RT-PCR was used to detect the expression of …

Activation of Wnt/β-catenin signaling played a crucial role in tumorigenesis, and β-catenin
(CTNNB1) overexpression has been identified in numerous solid tumors. The present study …

Dysregulation of γ-catenin may function as an oncogenic factor in various malignancies. We
investigated γ-catenin expression in acute myeloid leukemia (AML) and explored its role in …

Objective To investigate the expressions of CDX2 and β-catenin and their correlation in
acute myeloid leukemia (AML). Methods Real-time PCR was used to examine the …

Abstract γ-catenin plays different roles in different types of tumors, and its role in chronic
myeloid leukemia (CML) cells has yet to be identified. In our study, two CML cell lines (K562 …

Canonical Wnt signaling regulates the transcription of T-cell factor (TCF)-responsive genes
through the stabilization and nuclear translocation of the transcriptional co-activator, β …

Acute lymphoblastic leukemia (ALL) is an aggressive hematologic neoplastic disorder that
arises from the clonal expansion of transformed T-cell or B-cell precursors. Thanks to …