Malignancy is defined by a set of abnormal biological capacities, termed the hallmarks of
cancer. Decades of histopathologic assessment and molecular profiling of human tumors …

Background: Somatic genomic aberrations are acquired within the context of germline
genomes which differ across individuals at millions of polymorphic sites. However, the role …

Tumors with the same diagnosis can have different molecular profiles and response to
treatment. It remains unclear when and why these differences arise. Somatic genomic …

The formation of tumors is complex and multifaceted, involving cancer cell–intrinsic and–
extrinsic factors. An important influence on tumorigenesis is the immune system, by which …

Cancers evade the immune system in order to grow or metastasise through the process of
cancer immunoediting. While immune checkpoint inhibitors have been effective for …

As cancers develop and spread they must continually evade immune destruction.
Understanding mechanisms of immune evasion in cancer is clinically significant as …

Despite recent advances in cancer immunotherapy, the process of immunoediting early in
tumorigenesis remains obscure. Here, we employ a mathematical model that utilizes the …

Cancers evade the immune system through the process of cancer immunoediting. While
immune checkpoint inhibitors are effective for reactivating tumour immunity in some cancer …

Cancer immunoediting, a hallmark of cancer, predicts that lymphocytes recognize tumor-
specific mutations (neoantigens) to kill immunogenic tumor cells and select less …

Genetic evolution that occurs during cancer progression enables tumour heterogeneity,
thereby fostering tumour adaptation, therapeutic resistance and metastatic potential …