Myocardial damage is the most serious pathological consequence of cardiovascular
diseases and an important reason for their high mortality. In recent years, because of the …

Mitochondria are primarily responsible for providing the contracting cardiac myocyte with a
continuous supply of ATP. However, mitochondria can rapidly change into death-promoting …

The endothelium is vital to the proper functioning in the heart, in particular due to its
production of nitric oxide (NO) which regulates vascular tone. Damage to the endothelium …

The resurgence of mitochondrial biology research stems from the realization that the distinct
regulation of mitochondria to meet diverse homeostatic demands is driven by exquisite …

The cardiac microvascular system, which is primarily composed of monolayer endothelial
cells, is the site of blood supply and nutrient exchange to cardiomyocytes. However …

Cardiovascular diseases (CVDs) are serious public health issues and are responsible for
nearly one-third of global deaths. Mitochondrial dysfunction is accountable for the …

Hypertension remains an important modifiable risk factor for cardiovascular disease,
associated with increased morbidity and mortality. Deciphering the mechanisms involved in …

The eukaryote's mitochondrial network is perhaps the cell's most sophisticated and dynamic
responsive sensing system. Integrating metabolic, oxygen, or danger signals with inputs …

Altered mitochondrial function is currently recognized as an important factor in
atherosclerosis initiation and progression. Mitochondrial dysfunction can be caused by …

Acute myocardial infarction is the leading cause of cardiovascular‑related mortality and
chronic heart failure worldwide. As regards treatment, the reperfusion of ischemic tissue …