Reperfusion therapy must be applied as soon as possible to attenuate the ischemic insult of
acute myocardial infarction (AMI). However reperfusion is responsible for additional …

Despite major progress in interventional and medical treatments, myocardial infarction (MI)
and subsequent development of heart failure (HF) are still associated with high mortality …

The consequence of myocardial ischemia is energetic stress, while reperfusion is
accompanied by abrupt ionic shifts and considerable oxidative stress. Cells die by apoptotic …

A large body of evidence indicates the existence of a complex pathophysiological
relationship between cardiovascular diseases and cancer. Mitochondria are crucial …

Mitochondria have long been known to play a critical role in maintaining the bioenergetic
status of cells under physiological conditions. It was also recognized early in mitochondrial …

Cardiomyocytes are subjected to the intense mechanical stress and metabolic demands of
the beating heart. It is unclear whether these cells, which are long-lived and rarely renew …

Mitochondrial dysfunction underlies many prevalent diseases including heart disease
arising from acute ischemia/reperfusion (I/R) injury. Here, we demonstrate that mitophagy …

Mitochondria produce large amounts of free radicals and play an important role in the life
and death of a cell. Thus, mitochondrial oxidative damage and dysfunction contribute to a …

Excess generation of reactive oxygen species (ROS) and cytosolic calcium accumulation
play major roles in the initiation of programmed cell death during acute myocardial …

Ischemic heart disease is a significant cause of morbidity and mortality in Western society.
Although interventions, such as thrombolysis and percutaneous coronary intervention, have …