Biomineralized scaffolds are an attractive option for bone tissue engineering, being similar
to native bone. However, optimization is difficult, due to the complex interplay among …

The need of synthetic bone grafts that recreate from macro-to nanoscale level the
biochemical and biophysical cues of bone extracellular matrix has been a major driving …

The production of bone-, dentine-and enamel-like biomaterials for the engineering of
mineralized (hard) tissues is a high-priority in regenerative medicine and dentistry. An …

Obtaining rapid mineralisation is a challenge in current bone graft materials, which has been
attributed to the difficulty of guiding the biological processes towards osteogenesis …

With limited availability of auto-and allografts, there is increasing demand for alternative
bone repair and regeneration materials. Inspired by a mimetic approach, the utility of …

Bone tissue engineering utilizes three critical elements–cells, scaffolds, and bioactive factors–
to recapitulate the bone tissue microenvironment, inducing the formation of new bone …

Successful regeneration of large segmental bone defects remains a major challenge in
clinical orthopedics, thus it is of important significance to fabricate a suitable alternative …

Augmentation of regenerative osteogenesis represents a premier clinical need, as hundreds
of thousands of patients are left with insufficient healing of bony defects related to a host of …

Engineering biomaterials that mimic the extracellular matrix (ECM) of bone is of significant
importance since most of the outstanding properties of the bone are due to matrix …

Three-dimensional scaffolds are known to directly influence proliferation and differentiation
of mesenchymal stem cells into bone tissue due to their properties such as stiffness and …