Abstract Background Neural tube defects (NTDs) are common birth defects (~ 1 in 1000
pregnancies in the US and Europe) that have complex origins, including environmental and …

Background Neural Tube Defects (NTDs) are among the most prevalent and most severe
congenital malformations worldwide. Polymorphisms in key genes involving the folate …

Neural tube defects (NTDs) are among the commonest human birth defects, affecting around
1 per 1,000 births [Copp et al., 2003]. A genetic basis for NTDs is implicated based on the …

In this paper, we trace the history of current research into the genetic and biochemical
mechanisms that underlie folate‐preventable neural tube defects (NTDs). The inspired …

Objective: To investigate the contribution of polymorphic variation in genes involved in the
folate-dependent homocysteine pathway in the aetiology of neural tube defects (NTD) …

The risk of neural tube defects (NTDs) is known to have a significant genetic component that
could act through either the NTD patient and/or maternal genotype. The success of folic acid …

Neural tube defects (NTDs) are the second most common birth defects (1 in 1000 live births)
in the world. Periconceptional maternal folate supplementation reduces NTD risk by 50 …

The role of susceptibility genes in the etiology of birth defects is unclear, but may involve in
some cases multiple alleles at multiple loci. We suggest a simple epidemiologic approach to …

Abstract Background Neural tube defects (NTDs) are birth defects of the brain, spine, or
spinal cord invoked by the insufficient intake of folic acid in the early stages of pregnancy …

Epidemiological studies have evaluated the association between maternal
methylenetetrahydrofolate reductase (MTHFR) C677T, A1298C and methionine synthase …