We examined the responses of basilar arteries taken from Otsuka Long-Evans Tokushima
Fatty (OLETF) rats, a type 2 diabetes model. Both the nitric oxide (NO)-mediated relaxation …

Superoxide anion can modulate vascular smooth muscle tone and is potentially involved in
diabetic vascular complications. The present study was undertaken to characterize both …

Objective: The goal was to identify the role of NAD (P) H oxidase in cerebrovascular
dysfunction in type 1 diabetes mellitus (T1D). Methods: In a first series of studies, rats were …

Background Cardiovascular disease is the leading cause of mortality in diabetics, and it has
a complex etiology that operates on several levels. Endothelial dysfunction and increased …

This study was aimed to characterize the vascular production of superoxide in Otsuka Long-
Evans Tokushima Fatty (OLETF) rat, a model of type 2 diabetes. The nitroblue tetrazolium …

Elevated oxidative stress plays a key role in the development of atherosclerosis and
endothelial dysfunction in diabetes-associated vascular disease. Glucose-induced changes …

It is well established that oxidative stress is enhanced in diabetes. However, the major in
vivo source of oxidative stress is not clear. Here we show that vascular NAD (P) H oxidase …

A growing body of evidence has shown that oxidative stress may be involved in the
development of vascular complications associated with diabetes. However, the molecular …

Elevated oxidative stress plays a key role in diabetes‐associated vascular disease. In this
study, we tested the hypothesis that high glucose‐induced oxidative stress was associated …

Background—Increased superoxide production contributes to reduced vascular nitric oxide
(NO) bioactivity and endothelial dysfunction in experimental models of diabetes. We …