Lung perfusion magnitude and distribution are essential for oxygenation and, potentially,
lung inflammation and protection during acute respiratory distress syndrome (ARDS). Yet …

Regional pulmonary perfusion (Q) has been investigated using blood volume (Fb) imaging
as an easier-to-measure surrogate. However, it is unclear if changing pulmonary conditions …

Changes in the spatial distribution of perfusion during acute lung injury and their impact on
gas exchange are poorly understood. We tested whether endotoxemia caused …

Rationale: The contribution of aeration heterogeneity to lung injury during early mechanical
ventilation of uninjured lungs is unknown. Objectives: To test the hypotheses that a strategy …

Objectives: Determine the intra-tidal regional gas and blood volume distributions at different
levels of atelectasis in experimental lung injury. Test the hypotheses that pulmonary aeration …

Introduction Spatial heterogeneity of lung aeration and strain (change volume/resting
volume) occurs at microscopic levels and contributes to lung injury. Yet, it is mostly assessed …

Purpose: To determine whether positive end-expiratory pressure (PEEP) would change the
altered regional pulmonary perfusion pattern caused by oleic acid (OA)-induced acute lung …

Lung recruitment maneuvers can help open collapsed lung units for sufficient oxygenation,
and positive end expiratory pressure (PEEP) is used to keep the lung open after recruitment …

Background The recruitment-to-inflation ratio (R/I) has been recently proposed to bedside
assess response to PEEP. The impact of PEEP on ventilator-induced lung injury depends on …

Background: Mechanical ventilation (MV) may initiate or worsen lung injury, so-called
ventilator-induced lung injury (VILI). Although different mechanisms of VILI have been …