Cancer is one of the leading causes of death. Globally a huge number of deaths and new
incidences are reported annually. Heterocyclic compounds have been proved to be very …

Background: Cancer is one of the major causes of human mortality worldwide. A number of
existing antineoplastic medications and treatment regimens are already working in the field …

Cancer is a large group of diseases that can affect any organ or body tissue due to the
abnormal cellular growth with the unknown reasons. Many of the existing chemotherapeutic …

A novel 3-(substituted benzylideneamino)-7-chloro-2-phenyl quinazoline-4 (3H)-one (7–27)
has been synthesized and characterised by IR, 1H NMR, 13C NMR spectroscopy, and …

EGFR has a key role in cell growth. Its mutation and overexpression share in epithelial
malignancies and tumor growth. Quinazoline and quinoline derivatives are common …

Quinazoline derivatives are fused heterocyclic ring systems which have been explored for
their inhibitory activity towards various protein kinase enzymes and their role as anticancer …

Angiogenesis, the formation of new blood vessels from the existing vasculature, is pivotal in
the migration, growth, and differentiation of endothelial cells in normal physiological …

Introduction: Quinazoline is one of the most studied moieties in medicinal chemistry due to
the wide range of biological properties such as the anticancer, antibacterial, anti …

EGFR, which plays a vital role as a regulator of cell growth, is one of the intensely studied TK
targets of anticancer inhibitors. The most two common anticancer inhibitors are …

Abstract Novel 2-chloro-4-anilino-quinazolines designed as EGFR and VEGFR-2 dual
inhibitors were synthesized and evaluated for inhibitory effects. EGFR and VEGFR-2 are …