The pancreatic islets are one of the most vascularized organs of the body. This likely reflects
the requirements of the organ for a rich supply of nutrients and oxygen to the tissue, as well …

The microvasculature is a key interface between blood and tissues and participates in
numerous pathophysiological processes. The heterogeneity of microvascular endothelial …

The pancreatic islet is highly vascularised, with an extensive capillary network. In addition to
providing nutrients and oxygen to islet endocrine cells and transporting hormones to the …

The intra-islet microvasculature is a critical interface between the blood and islet endocrine
cells governing a number of cellular and pathophysiological processes associated with the …

Islet transplantation has become a widely accepted therapeutic option for selected patients
with type 1 diabetes mellitus. However, in order to achieve insulin independence a great …

Insulin-producing β-cells constitute the majority of the cells in the pancreatic islets.
Dysfunction of these cells is a key factor in the loss of glucose regulation that characterizes …

The islets of Langerhans consist of endocrine cells embedded in a network of specialized
capillaries that regulate islet blood flow. Despite evidence for a critical role of islet perfusion …

Pancreatic islet transplantation has emerged as a therapy for type 1 diabetes and is today
performed using both freshly isolated and cultured islets. Islet blood vessels are disrupted …

Pancreatic islet transplantation is an emerging therapy for type 1 diabetes. To survive and
function, transplanted islets must revascularize because islet isolation severs arterial and …

Abstract Background/Aims: An important reason for the large amount of islets required for
successful islet transplantation is likely to be inadequate engraftment of the transplanted …