Pancreatic islets are clusters of hormone-secreting endocrine cells that rely on intricate cell-
cell communication mechanisms for proper function. The importance of multicellular …

Pancreatic islet transplantation is a promising therapy to regain glycemic control in diabetic
patients. The selection of ideal grafts is the basis to guarantee short‐term effectivity and …

To discuss the controversy of the current concept of islet microcirculation, an international
symposium was held at the Long Beach Veterans Administration Regional Medical …

For their survival and optimal function, pancreatic islets depend posttransplantation on a
rapid and adequate revascularization. Native islets display a marked size-dependent …

With the inception of the Edmonton Protocol, intraportal islet transplantation (IPIT) has re-
emerged as a promising cell-based therapy for type 1 diabetes. However, current clinical …

Pancreatic islet transplantation is a therapeutic option to replace destroyed β cells in
autoimmune diabetes. Islets are transplanted into the liver via the portal vein; however …

Successful islet transplantation depends on the infusion of sufficiently large quantities of
islets, of which only∼ 30% become stably engrafted. Rapid and adequate revascularization …

Lack of rapid revascularization and inflammatory attacks at the site of transplantation
contribute to impaired islet engraftment and suboptimal metabolic control after clinical islet …

There is evidence that intraislet cellular communication and hormone delivery within the
islets of Langerhans is controlled via capillary perfusion directed from the B cell core to the …

Clinical islet transplantation has recently received a the journal has made to the field as this
new era for islet transplantation begins. strong impulse from the results obtained with the …