Extracellular matrix (ECM) molecules are responsible for structural and biochemical support,
as well as for regulation of molecular signalling and tissue repair in many organ structures …

Pancreatic islet transplantation as a therapeutic option for type 1 diabetes mellitus is gaining
widespread attention because this approach can restore physiological insulin secretion …

In pancreatic islet transplantation, revascularization is crucial for the graft's survival and
function. In this study, the endothelium of isolated islets and revascularization and function of …

Over the last two decades we have focused on beta cell signal transduction, bringing many
new insights, especially in the context of insulin signal transduction, the role of inositol …

Abstract Background/Aims: To obtain a selective marker to identify endothelial cells is
difficult, due to the heterogeneity of these cells. Most described markers perform well in …

Blood glucose homeostasis requires proper function of pancreatic islets, which secrete
insulin, glucagon and somatostatin from the β-, α-and δ-cells respectively. Each islet cell …

Objective To review the current progress of islet cell transplantation in patients with insulin-
dependent diabetes, emphasizing on the difficulties with recovering and preserving islet cell …

A large proportion of islets are lost after transplantation partly due to a lack of functional
vasculature. Islets revascularize from host tissue but the process takes up to 2 weeks and …

Direct in vivo assessment of pancreatic islet-cells for the study of the pathophysiology of
diabetes in humans is hampered by anatomical and technological hurdles. To date, most of …

This review focuses on the human pancreatic islet—including its structure, cell composition,
development, function, and dysfunction. After providing a historical timeline of key …