Excess myocardial triacylglycerol accumulation (ie, cardiac steatosis) impairs heart function,
suggesting that enzymes promoting triacylglycerol metabolism exert essential regulatory …

Adipose triglyceride lipase (ATGL) was recently identified as a rate-limiting triglyceride (TG)
lipase and its activity is stimulated by comparative gene identification-58 (CGI-58). Mutations …

Efficient catabolism of cellular triacylglycerol (TG) stores requires the TG hydrolytic activity of
adipose triglyceride lipase (ATGL). The presence of comparative gene identification-58 (CGI …

Intramyocellular accumulation of lipids is often associated with insulin resistance. Deficiency
of comparative gene identification-58 (CGI-58) causes cytosolic deposition of triglyceride …

Mutations of Comparative Gene Identification-58 (CGI-58) in humans cause triglyceride (TG)
accumulation in multiple tissues. Mice genetically lacking CGI-58 die shortly after birth due …

Cellular TG stores are efficiently hydrolyzed by adipose TG lipase (ATGL). Its coactivator
comparative gene identification-58 (CGI-58) strongly increases ATGL-mediated TG …

Abstract Comparative Gene Identification-58 (CGI-58), as an adipose triglyceride lipase
(ATGL) activator, strongly increases ATGL-mediated triglyceride (TG) catabolism. Previous …

Adipose triglyceride lipase (ATGL) and comparative gene identification 58 (CGI-58) are
critical regulators of triacylglycerol (TAG) turnover. CGI-58 is thought to regulate TAG …

We investigated here the specific role of CGI-58 in the regulation of energy metabolism in
skeletal muscle. We first examined CGI-58 protein expression in various muscle types in …

Diabetic cardiomyopathy (DCM) accounts for increasing deaths of diabetic patients, and
effective therapeutic targets are urgently needed. Myocardial lipotoxicity, which is caused by …