Myostatin is a negative regulator of skeletal muscle growth and in fact acts as a potent
inducer of “cachectic-like” muscle wasting in mice. The mechanism of action of myostatin in …

Myostatin is a negative regulator of skeletal muscle size, previously shown to inhibit muscle
cell differentiation. Myostatin requires both Smad2 and Smad3 downstream of the activin …

Myostatin is an endogenous, negative regulator of muscle growth determining both muscle
fiber number and size. The myostatin pathway is conserved across diverse species ranging …

Myostatin was identified more than 20 years ago as a negative regulator of muscle mass in
mice and cattle. Since then, a wealth of studies have uncovered the potential involvement of …

Myostatin, a member of the transforming growth factor-β superfamily, is a potent negative
regulator of skeletal muscle growth and is conserved in many species, from rodents to …

Myostatin is an endogenous inhibitor of muscle conserved across diverse species. In the
absence of myostatin, there is massive muscle growth in mice, cattle, and humans. Previous …

Since its discovery in 1997, myostatin has quickly been established as a key regulator of
skeletal muscle mass. Recent developments strengthen the idea that myostatin will be an …

Myostatin is a powerful negative regulator of skeletal muscle mass in mammalian species. It
plays a key role in skeletal muscle homeostasis and has now been well described since its …

Myostatin is a master regulator of myogenesis and early postnatal skeletal muscle growth.
However, myostatin has been also involved in several forms of muscle wasting in adulthood …

As myostatin is a potent inducer of muscle wasting, antagonists to myostatin have been
speculated to have great therapeutic value in alleviating muscle wasting. Indeed, myostatin …