Recently developed CRISPR-mediated base editors, which enable the generation of
numerous nucleotide changes in target genomic regions, have been widely adopted for …

Precise replacement of an allele with an elite allele controlling an important agronomic trait
in a predefined manner by gene editing technologies is highly desirable in crop …

Cytidine and adenosine deaminases are required for cytosine and adenine editing of base
editors respectively, and no single deaminase could enable concurrent and comparable …

Alfalfa (Medicago sativa) is an outcrossing tetraploid legume species widely cultivated in the
world. The clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR …

Adenine base editors (ABEs) catalyze specific A-to-G conversions at genomic sites of
interest. However, ABEs also induce cytosine deamination at the target site. To reduce the …

Planted to two million ha farmland and yielding more than 70 million tons per year,
watermelon dominates the fruit market in China. However, with a low planting density and …

Establishing saturated mutagenesis in a specific gene through gene editing is an efficient
approach for identifying the relationships between mutations and the corresponding …

accepted 22 November 2018.* Correspondence (Tel 86-551-65160535-807 (PW) and 86-
010-62737131 (XZ); fax 86-551-65145277 (PW) and 86-010-62737131 (XZ); emails …

Prime editing is a novel and universal CRISPR-Cas-derived precise genome-editing
technology and has great potentials for applications in basic plant research and crop …

CRISPR/Cas9 (clustered regularly interspaced short palindromic repeats/CRISPR-
associated Cas9) has been widely used in genome editing in a variety of organisms …