A critical role for IL-17, a cytokine produced by T helper 17 (Th17) cells, has been indicated
in the pathogenesis of chronic inflammatory and autoimmune diseases. A positive effect of …

Cytokines of the IL-17 family are uniquely placed on the border between immune cells and
tissue. Although IL-17 was originally found to induce the activation and mobilization of …

Neurodegenerative diseases are characterized by the loss of neurons and/or myelin sheath,
which deteriorate over time and cause dysfunction. Interleukin 17A is the signature cytokine …

It has been firmly established that IL-23 polarized TH17 cells are potent effectors in the
pathogenesis of experimental autoimmune encephalitomyelitis (EAE). However, the relative …

The role of T helper 17 (Th17) cells in auto-inflammatory neurological disorders such as
Multiple Sclerosis (MS), Alzheimer's disease (AD), Parkinson's disease (PD) and …

ABSTRACT Interleukin-12 (IL-12) has long been considered essential in T-cell-mediated
autoimmune diseases, including multiple sclerosis (MS) and its animal model, experimental …

Recently published studies in multiple sclerosis (MS) and experimental autoimmune
encephalomyelitis (EAE) have demonstrated an association between the development of …

Experimental autoimmune encephalomyelitis (EAE) is widely regarded as an animal model
of the human disease multiple sclerosis. A multitude of studies has investigated the …

IL-17 (interleukin-17), a hallmark cytokine of Th17 (T-helper 17) cells, plays critical roles in
host defence against bacterial and fungal infections, as well as in the pathogenesis of …

Neurological disorders (NDs) are one of the leading causes of global death. A sustained
neuroinflammatory response has been reported to be associated with the pathogenesis of …