Background Infantile spasms is a severe infantile seizure disorder that is difficult to treat and
has a high morbidity. Absence of spasms on days 13 and 14 after randomisation is more …

Background Infantile spasms is the name given to a difficult to treat, severe infantile epilepsy
with high morbidity. The United Kingdom Infantile Spasms Study (UKISS) showed that …

Background Infantile spasms constitute a severe form of epileptic encephalopathy. In the
International Collaborative Infantile Spasms Study (ICISS), we showed that combining …

Background Infantile spasms constitutes a severe infantile epilepsy syndrome that is difficult
to treat and has a high morbidity. Hormonal therapies or vigabatrin are the most commonly …

Background Infantile spasms, which comprise a severe infantile seizure disorder, have a
high morbidity and are difficult to treat. Hormonal treatments (adrenocorticotropic hormone …

Purpose: The efficacy and tolerability of vigabatrin (VGB) as an add‐on therapy in the
treatment of infantile spasm (IS) prompted physicians to explore its use as the first drug in …

Purpose: To compare the efficacy and tolerability of vigabatrin (VGB) and
adrenocorticotrophic hormone (ACTH) as first‐line therapy in infantile spasms. Methods …

Purpose: Infantile spasms is a severe infantile seizure disorder. Several factors affect
developmental outcome, especially the underlying etiology of the spasms. Treatment also …

The treatment of infantile spasms is challenging, especially in the context of the following:(1)
a severe phenotype with high morbidity and mortality;(2) the urgency of diagnosis and …

A large randomized study was conducted in patients with newly diagnosed infantile spasms
to compare 2 doses of vigabatrin in achieving spasm cessation. High (100-148 mg/kg/d) and …