Background: The minimum clinically important difference (MCID) was developed to
ascertain the smallest change in an outcome that patients perceive as beneficial. The …

Methods: We designed a network meta-analysis to determine clinically relevant
effectiveness of nonsteroidal anti-inflammatory drugs, acetaminophen, intra-articular (IA) …

Objective This umbrella review aimed to summarize (and update) the effectiveness of non-
pharmacological and non-surgical interventions for patients with knee osteoarthritis …

Background In contrast to best practice guidelines for knee osteoarthritis (OA), findings from
several different healthcare settings have identified that nonsurgical treatments are …

Background: The relative efficacy of available treatments of knee osteoarthritis (OA) must be
determined for rational treatment algorithms to be formulated. Purpose: To examine the …

Background: Guidelines recommending various nonoperative treatments for patients with
knee osteoarthritis remain inconsistent. Much of this controversy relates to what constitutes a …

Introduction It is recommended that non-operative treatment of knee osteoarthritis (KOA)
should be individually tailored and include multiple treatment modalities. Despite these …

Objectives To systematically review and provide estimates of the minimal important change
(MIC) and difference (MID) for outcome tools in people with knee osteoarthritis (OA) after …

Introduction The AAOS Evidence-Based Guideline on Treatment of Osteoarthritis of the
Knee, 2nd Edition, includes only less-invasive alternatives to knee replacement. This brief …

The following is a summary of the recommendations in the AAOS'clinical practice guideline,
The Treatment of Osteoarthritis (OA) of the Knee. This guideline was explicitly developed to …