Essential role of neutrophils in germ cell-specific apoptosis following ischemia/reperfusion injury of the mouse testis
JJ Lysiak, SD Turner, QAT Nguyen… - Biology of …, 2001 - academic.oup.com
This study investigates the role of neutrophils in ischemia-induced aspermatogenesis in the
mouse. Previous studies in the rat have demonstrated that ischemia-inducing testicular …
mouse. Previous studies in the rat have demonstrated that ischemia-inducing testicular …
Ischemia-reperfusion of the murine testis stimulates the expression of proinflammatory cytokines and activation of c-jun N-terminal kinase in a pathway to E-selectin …
JJ Lysiak, QAT Nguyen, JL Kirby… - Biology of …, 2003 - academic.oup.com
Ischemia-reperfusion (IR) of the testis results in germ cell-specific apoptosis and can lead to
aspermatogenesis. Germ cell-specific apoptosis after IR of the testis has been shown to be …
aspermatogenesis. Germ cell-specific apoptosis after IR of the testis has been shown to be …
Acute testicular ischemia results in germ cell-specific apoptosis in the rat
TT Turner, KSK Tung, H Tomomasa… - Biology of …, 1997 - academic.oup.com
Testis torsion-induced aspermatogenesis is not necessarily due to permanent loss of blood
flow nor to dysfunctional Leydig cells or Sertoli cells. This investigation was undertaken to …
flow nor to dysfunctional Leydig cells or Sertoli cells. This investigation was undertaken to …
Molecular pathway of germ cell apoptosis following ischemia/reperfusion of the rat testis
JJ Lysiak, SD Turner, TT Turner - Biology of reproduction, 2000 - academic.oup.com
The present study investigates the molecular apoptotic pathway in germ cells following
acute ischemia of the rat testis. Rats were subjected to ischemia-inducing torsion and testes …
acute ischemia of the rat testis. Rats were subjected to ischemia-inducing torsion and testes …
Nitric oxide promotes germ cell necrosis in the delayed phase after experimental testicular torsion of rat
K Shiraishi, K Naito, K Yoshida - Biology of reproduction, 2001 - academic.oup.com
The purpose of this study is to determine whether inducible nitric oxide synthase (iNOS) is
involved in the pathogenesis of testicular ischemia-reperfusion (I/R) injury in association …
involved in the pathogenesis of testicular ischemia-reperfusion (I/R) injury in association …
Caspase-9-dependent pathway to murine germ cell apoptosis: mediation by oxidative stress, BAX, and caspase 2
JJ Lysiak, S Zheng, R Woodson, TT Turner - Cell and Tissue Research, 2007 - Springer
Ischemia-reperfusion (IR) of the testis results in germ-cell-specific apoptosis (GCA) and a
reduction in daily sperm production. This has been correlated with and is dependent upon …
reduction in daily sperm production. This has been correlated with and is dependent upon …
Peptide and nonpeptide reactive oxygen scavengers provide partial rescue of the testis after torsion
JJ Lysiak, QAT Nguyen, TT Turner - Journal of andrology, 2002 - Wiley Online Library
Ischemia‐reperfusion (IR) of the testis results in germ cell‐specific apoptosis, followed by a
reduction in testis weight and daily sperm production (DSP). This has been associated with …
reduction in testis weight and daily sperm production (DSP). This has been associated with …
The molecular pathology of experimental testicular torsion suggests adjunct therapy to surgical repair
TT Turner, HJ Bang, JL Lysiak - The Journal of urology, 2004 - auajournals.org
Purpose: We review the work of our laboratory in discovering the pathophysiological
mechanisms that underpin testicular response to testicular torsion. Evidence from animal …
mechanisms that underpin testicular response to testicular torsion. Evidence from animal …
Germ cell apoptosis and endothelial nitric oxide synthase (eNOS) expression following ischemia-reperfusion injury to testis
A Zini, J Abitbol, SK Girardi, D Schulsinger… - Archives of …, 1998 - Taylor & Francis
There is evidence to suggest that reactive oxygen species (ROS) are involved in ischemia-
reperfusion injury to the testis. Nitric oxide (NO), a ubiquitous free radical produced by the …
reperfusion injury to the testis. Nitric oxide (NO), a ubiquitous free radical produced by the …
[HTML][HTML] Glucocorticoid hormone can suppress apoptosis of rat testicular germ cells induced by testicular ischemia
H Yazawa, I Sasagawa, Y Suzuki, T Nakada - Fertility and sterility, 2001 - Elsevier
Objective: To evaluate the effect of dexamethasone, a potent synthetic glucocorticoid
hormone, on apoptosis of testicular germ cells and vascular neutrophil adhesion after repair …
hormone, on apoptosis of testicular germ cells and vascular neutrophil adhesion after repair …