Rationale Specific brain structures have been suggested to be involved in impulsive
responding assessed by a variety of operant tasks. Central serotonin (5-HT) function has …

Reducing levels of 5-HT in the central nervous system has been associated with increases
in impulsive behavior. However, the impulsivity construct describes a wide range of …

Converging lines of evidence suggest that dysfunction of brain serotonergic systems may
underlie impulsive behavior. However, the nature of this deficit remains poorly understood …

Impulsivity is an important feature of multiple neuropsychiatric disorders, and individual
variation in the degree of inherent impulsivity could play a role in the generation or …

Impulsivity or diminished inhibitory control of behavior (impulse control) is a prominent
feature of several neuropsychiatric diseases. Serotonin (5-HT) plays an important role in …

The relationship between impulsivity and drug abuse is poorly understood despite evidence
that impulsive behaviour both predicts, and is a consequence of, drug use. Moreover …

Impulsivity is a multi-faceted personality construct that plays a prominent role in drug abuse
vulnerability. Dysregulation of 5-hydroxytryptamine (serotonin, 5-HT) systems in subregions …

Animal models are making an increasing contribution to our understanding of the
psychology and brain mechanisms underlying behavioral inhibition and impulsivity. The aim …

Abstract Rationale Global serotonin (5-HT) depletion increases the number of premature
responses made on the five-choice serial reaction time task (5CSRT) in rats. In contrast, the …

Abstract Serotonin (5-HT) is thought to play an important role in the regulation of behavioral
inhibition. Studies manipulating 5-HT function in the rodent brain indicate that 5-HT …