5-HT system and cognition

A Meneses - Neuroscience & Biobehavioral Reviews, 1999 - Elsevier
The study of 5-hydroxytryptamine (5-HT) system has benefited from the identification,
classification and cloning of multiple 5-HT receptors (5-HT1 to 5-HT7). Growing evidence …

Effects of 5-HT4 receptor agonists and antagonists in learning

A Meneses, E Hong - Pharmacology Biochemistry and Behavior, 1997 - Elsevier
In the present work, the effects of pre-or post-training (ip) injection of BIMU1 and BIMU8 (5-
HT4 agonists) were figured out in the autoshaping learning task. Furthermore, the post …

Blockade of noradrenaline re-uptake sites improves accuracy and impulse control in rats performing a five-choice serial reaction time tasks

ESJ Robinson - Psychopharmacology, 2012 - Springer
Rationale Atomoxetine, reboxetine and methylphenidate all act at the noradrenaline
transporter (NAT) and atomoxetine and methylphenidate are licensed for the treatment of …

Role of medial prefrontal and orbitofrontal monoamine transporters and receptors in performance in an adjusting delay discounting procedure

JR Yates, JL Perry, AC Meyer, CD Gipson, R Charnigo… - Brain Research, 2014 - Elsevier
Performance in an adjusting delay discounting procedure is predictive of drug abuse
vulnerability; however, the shared underlying specific prefrontal neural systems linking delay …

Prefrontal and monoaminergic contributions to stop-signal task performance in rats

A Bari, AC Mar, DE Theobald, SA Elands… - Journal of …, 2011 - Soc Neuroscience
Defining the neural and neurochemical substrates of response inhibition is of crucial
importance for the study and treatment of pathologies characterized by impulsivity such as …

The relationship between impulsive choice and impulsive action: a cross-species translational study

N Broos, L Schmaal, J Wiskerke, L Kostelijk, T Lam… - PloS one, 2012 - journals.plos.org
Maladaptive impulsivity is a core symptom in various psychiatric disorders. However, there is
only limited evidence available on whether different measures of impulsivity represent …

Serotonin releasers increase prepulse inhibition in serotonin 1B knockout mice

SC Dulawa, KA Scearce-Levie, R Hen, MA Geyer - Psychopharmacology, 2000 - Springer
Rationale: Prepulse inhibition (PPI) is the normal reduction of the startle response which
occurs when an abrupt startling stimulus is preceded by a weak pre-stimulus and is …

Enhanced discriminative aversive learning and amygdala responsivity in 5-HT transporter mutant mice

J Lima, T Sharp, DM Bannerman, SB McHugh - Translational psychiatry, 2019 - nature.com
Genetic variation in the human serotonin transporter (5-HTT) has been linked to altered fear
learning but the data are inconsistent and the mechanism is unclear. The present study …

8-OH-DPAT-induced effects on prepulse inhibition: pre-vs. post-synaptic 5-HT1A receptor activation

A Gogos, S Kusljic, M van den Buuse - Pharmacology Biochemistry and …, 2005 - Elsevier
Prepulse inhibition (PPI) is a measure of sensorimotor gating that is deficient in
schizophrenia. In rats, administration of the serotonin-1A (5-HT1A) receptor agonist, 8 …

Inter-individual differences in the impulsive/compulsive dimension: deciphering related dopaminergic and serotonergic metabolisms at rest

F Dellu-Hagedorn, M Rivalan… - … of the Royal …, 2018 - royalsocietypublishing.org
Several impulse control disorders such as ADHD, mania, personality disorders or substance
abuse share common behavioural traits, like impulsiveness, risk-taking or inflexible …