The functions of the high-affinity glycine transporters (GLYTs) in vivo have been revealed
recently using gene-deletion studies. Results from studies of homozygous knockout mice …

High-affinity glycine transport in neurons and glial cells is a primary means of inactivating
synaptic glycine. We have synthesized a potent selective inhibitor of glycine transporter 1 …

N-methyl-D-aspartate (NMDA) receptor dysfunction may play a key role in the
pathophysiology of schizophrenia. Recent studies have investigated the ability of …

Traditional models of schizophrenia have focused primarily upon dopaminergic (DA)
dysregulation. In contrast, more recent models focus on dysfunction of glutamatergic …

The glutamatergic hypothesis of schizophrenia states that the positive, negative and
cognitive symptoms of this devastating disease originate with a deficit in transmission at the …

Glycine accomplishes several functions as a transmitter in the central nervous system
(CNS). As an inhibitory neurotransmitter, it participates in the processing of motor and …

The development of glycine transporter 1 (GlyT1) inhibitors may offer putative treatments for
schizophrenia and other disorders associated with hypofunction of the glutaminergic N …

J. Neurochem.(2010) 114, 647–653. Abstract Glycine transporter 1 (GLYT1) and GLYT2 are
the glycine transporters in CNS. While GLYT2 is largely expressed in glycinergic neurons …

Rationale Since the hypofunction of the N-methyl-D-aspartate (NMDA) receptor is known to
be involved in the pathophysiology of schizophrenia, the enhancement of NMDA receptor …

Elevation of glycine levels and activation of the NMDA receptor by inhibition of the glycine
transporter 1 (GlyT-1) is a potential strategy for the treatment of schizophrenia. A novel …