Chronic exposure to opioids induces adaptations in brain function that lead to the formation
of the behavioral and physiological symptoms of drug dependence and addiction. Animal …

Prescription opioid abuse, for example of oxycodone, is a pressing public health issue. This
study focuses on how chronic oxycodone self-administration (SA) affects the reward …

Chronic opioid intake leads to several brain changes involved in the development of
dependence, whereby an early hedonistic effect (liking) extends to the need to self …

Neuroadaptations in the ventral striatum (VS) and ventral midbrain (VMB) following chronic
opioid administration are thought to contribute to the pathogenesis and persistence of opiate …

Repeated opiate administration alters gene expression in different brain regions of rodents,
an effect which may contribute to plastic changes associated with addictive behaviour. There …

Repeated exposure to the opioid agonist, oxycodone, can lead to addiction. Here, we
sought to identify potential neurobiological consequences of withdrawal from escalated and …

Opioid use disorder is a serious public health issue in the United States. Animal models of
opioid dependence are fundamental for studying the etiology of addictive behaviors. We …

Background Opioid abuse is a chronic disorder likely involving stable neuroplastic
modifications. While a number of molecules contributing to these changes have been …

Use of prescription opioids, particularly oxycodone, is an initiating factor driving the current
opioid epidemic. There are several challenges with modelling oxycodone abuse. First …

Highlights•Alterations in endogenous opioid system components occur in development of
addiction.•Human studies and animal models show opioid genes contribute to addiction …