Summary Insulin/IGF-1 signaling (IIS) regulates aging in worms, flies, and mice through a
well-characterized, highly conserved core set of components. IIS also regulates early …

In Caenorhabditis elegans, the insulin/IGF-1 signaling pathway controls many biological
processes such as life span, fat storage, dauer diapause, reproduction and stress response …

Twenty-nine years following the breakthrough discovery that a single-gene mutation of daf-2
doubles Caenorhabditis elegans lifespan, it remains unclear where this insulin/IGF-1 …

The Forkhead Box O transcription factor DAF-16 regulates genes affecting dauer larva
formation and adult life span. Expression profiling and genome-wide searches for DAF-16 …

Ageing is a fundamental, unsolved mystery in biology. DAF-16, a FOXO-family transcription
factor, influences the rate of ageing of Caenorhabditis elegans in response to insulin/insulin …

DAF-16, a forkhead transcription factor, is a key regulator of longevity, metabolism and
dauer diapause in Caenorhabditis elegans. The precise mechanism by which DAF-16 …

The roles and regulatory mechanisms of transcriptome changes during aging are unclear. It
has been proposed that the transcriptome suffers decay during aging owing to age …

More than 400 genes have been noted to modulate Caenorhabditis elegans longevity.
Recent studies testing the role of proposed secreted insulin-binding proteins unexpectedly …

The daf-2 insulin-like receptor pathway regulates development and life-span in
Caenorhabditis elegans. Reduced DAF-2 signaling leads to changes in downstream targets …

FOXO family transcription factors are downstream effectors of Insulin/IGF-1 signaling (IIS)
and major determinants of aging in organisms ranging from worms to man. The molecular …