daf-16 is a forkhead-type transcription factor, functioning downstream of insulin-like signals,
and is known to be critical to the regulation of life span in Caenorhabditis elegans …

Abstract Forkhead transcription factor, DAF-16, regulates genes that contribute both to
longevity and resistance to various stresses in C. elegans. We and others have reported that …

The insulin‐like signalling pathway is a central regulator of development, metabolism, stress
resistance and lifespan in eukaryotes. Caenorhabditis elegans daf‐2 (e1370) animals with a …

The nematode Caenorhabditis elegans has proven to be a very useful tool for studying the
genetics of longevity. Over 70 genes have been found to influence lifespan in this worm …

C. elegans insulin-like signaling regulates metabolism, development, and life span. This
signaling pathway negatively regulates the activity of the forkhead transcription factor DAF …

The insulin/insulin growth factor (IGF)‐like signaling (IIS) pathway has a conserved role in
regulating lifespan in Caenorhabditis elegans, Drosophila and mice. Extension of lifespan …

Abstract Background In the nematode, Caenorhabditis elegans, a conserved insulin-like
signaling pathway controls larval development, stress resistance and adult lifespan. AGE-1 …

We report here the first genome-wide functional genomic screen for longevity genes. We
systematically surveyed Caenorhabditis elegans genes using large-scale RNA interference …

Lifespan can be lengthened by genetic and environmental modifications. Study of these
might provide valuable insights into the mechanism of aging. Low doses of radiation and …

FoxO transcription factors promote longevity across taxa. How they do so is poorly
understood. In the nematode Caenorhabditis elegans, the A-and F-isoforms of the FoxO …