Reproduction and aging are intertwined. While lifespan and reproductive strategies vary
greatly among animals, the progeny production period generally... Aging in eukaryotes is …

Abstract O-linked-β-N-acetylglucosamine (O-GlcNAc) modification is a regulatory, nuclear
and cytoplasmic post-translational glycosylation of proteins associated with age-related …

The insulin-like signaling pathway maintains a relatively short wild-type lifespan in
Caenorhabditis elegans by phosphorylating and inactivating DAF-16, the ortholog of the …

In many organisms, dietary restriction appears to extend lifespan, at least in part, by down-
regulating the nutrient-sensor TOR (Target Of Rapamycin). TOR inhibition elicits autophagy …

Summary Insulin/IGF-1-like signaling (IIS) is central to growth and metabolism and has a
conserved role in aging. In C. elegans, reductions in IIS increase stress resistance and …

A Caenorhabditis elegans insulin-like signaling pathway regulates development,
metabolism, and longevity. We detected abundant DAF-2 insulin-like receptor protein mainly …

Intermittent fasting is one of the most effective dietary restriction regimens that extend life
span in C. elegans and mammals. Fasting-stimulus responses are key to the longevity …

Abstract Insulin/IGF-1 Signaling (IIS) is known to constrain longevity by inhibiting the
transcription factor FOXO. How phosphorylation mediated by IIS kinases regulates lifespan …

Most aging hypotheses assume the accumulation of damage, resulting in gradual
physiological decline and, ultimately, death. Avoiding protein damage accumulation by …

Evidence gathered over the past 15 years shows that the nematode Caenorhabditis elegans
is excellently suited as a model to study aging processes in the entire organism. Genetic …