In a remarkably conserved insulin signaling pathway that is well‐known for its regulation of
longevity in worms, flies, and mammals, the major C. elegans effector of this pathway, DAF …

Drosophila melanogaster and Caenorhabditis elegans each carry a single representative of
the Forkhead box O (FoxO) family of transcription factors, dFOXO and DAF-16, respectively …

From egg through adult, C. elegans has six life stages including an option for dauer
formation and diapause at larval stage L3 in adverse environments. Somatic cells …

Sarcopenia, defined as the loss of skeletal muscle mass and strength, contributes to
disability and health-related conditions with aging. In vitro studies indicate that age-related …

Modulation of insulin/IGF signaling in the nematode Caenorhabditis elegans is the central
determinant of the endocrine control of stress response, diapause, and aging. Mutations in …

In C. elegans, insulin‐like hormone signal pathway plays a significant role in longevity. In
particular, daf‐16 gene product is indispensable factor for this lifespan‐extension. This …

Insulin‐like signalling is a key determinate of lifespan in diverse species including mammals
but the mechanism by which this pathway influences the rate of aging is unknown. In the …

Stress is a fundamental aspect of aging, as accumulated damage from a lifetime of stress
can limit lifespan and protective responses to stress can extend lifespan. In this study, we …

The critical role of protein synthesis in regulating lifespan has been evidenced. This study
shows that adult‐onset RNAi inactivation of eukaryotic initiation factor 2Bδ (eIF2Bδ/F11A3 …

The DAF-16/FOXO transcription factor is the major downstream output of the insulin/IGF1R
signaling pathway controlling C. elegans dauer larva development and aging. To identify …