Proteins, RNAs and even large macromolecular complexes are transported into and out of
nuclei with remarkable rapidity and specificity. Nucleocytoplasmic transport must therefore …

Active transport between the nucleus and cytoplasm involves primarily three classes of
macromolecules: substrates, adaptors, and receptors. Some transport substrates bind …

In eukaryotic cells, cell functions are maintained in an orderly manner through the
continuous traffic of various proteins between the cell nucleus and the cytoplasm. The …

▪ Abstract The compartmentation of eukaryotic cells requires all nuclear proteins to be
imported from the cytoplasm, whereas, for example, transfer RNAs, messenger RNAs, and …

Significant and exciting advances in the field of RNA and protein export have been made
recently, due in large part to discovery of the roles played by Ran, a small, soluble GTPase …

抄録 The active transport of proteins into and out of the nucleus is mediated by specific
signals, the nuclear localzation signal (NLS) and nuclear export signal (NES), respectively …

The evolution of the nucleus imposed on eukaryotic cells the necessity to strictly control
exchange of molecules between the nucleus and the remainder of the cell, not only to …

Background: Transport of macromolecules between the nucleus and cytoplasm of eukaryotic
cells is mediated by nuclear import and export receptors. The receptors identified to date are …

A concentration gradient of the GTP-bound form of the GTPase Ran across nuclear pores is
essential for the transport of many proteins and nucleic acids between the nuclear and …

In eukaryotes, the nuclear membrane provides a physical barrier to the passive diffusion of
macromolecules from and into the cytoplasm. Nucleocytoplasmic traffic occurs through …