Modeling with a view to target identification in metabolic engineering: a critical evaluation of the available tools
J Maertens, PA Vanrolleghem - Biotechnology Progress, 2010 - Wiley Online Library
The state of the art tools for modeling metabolism, typically used in the domain of metabolic
engineering, were reviewed. The tools considered are stoichiometric network analysis …
engineering, were reviewed. The tools considered are stoichiometric network analysis …
[HTML][HTML] Engineering microbial chemical factories using metabolic models
D Sarkar, CD Maranas - BMC Chemical Engineering, 2019 - Springer
Living organisms in analogy with chemical factories use simple molecules such as sugars to
produce a variety of compounds which are necessary for sustaining life and some of which …
produce a variety of compounds which are necessary for sustaining life and some of which …
[HTML][HTML] A review of computational tools for design and reconstruction of metabolic pathways
Metabolic pathways reflect an organism's chemical repertoire and hence their elucidation
and design have been a primary goal in metabolic engineering. Various computational …
and design have been a primary goal in metabolic engineering. Various computational …
Modeling and simulation: tools for metabolic engineering
W Wiechert - Journal of biotechnology, 2002 - Elsevier
Mathematical modeling is one of the key methodologies of metabolic engineering. Based on
a given metabolic model different computational tools for the simulation, data evaluation …
a given metabolic model different computational tools for the simulation, data evaluation …
A structured approach for selection among candidate metabolic network models and estimation of unknown stoichiometric coefficients
PA Vanrolleghem, JJ Heijnen - Biotechnology and …, 1998 - Wiley Online Library
A metabolic network model is one of the cornerstones of the emerging Metabolic
Engineering methodology. In this article, special attention is therefore, given to the phase of …
Engineering methodology. In this article, special attention is therefore, given to the phase of …
[引用][C] Analysis and engineering of metabolic networks
ND Lindley - Biofutur, 1995 - Elsevier
ANALYSIS AND ENGINEERING OF METABOLIC NETWORKS Page 1 FERMENTATION
ANALYSIS AND ENGINEERING OF METABOLIC NETWORKS Nicholas D LINDLEY …
ANALYSIS AND ENGINEERING OF METABOLIC NETWORKS Nicholas D LINDLEY …
Modelling and analysis of metabolic pathways
JC Liao - Current opinion in biotechnology, 1993 - Elsevier
Modelling and analysis of metabolic pathways has received an increasing amount of
attention over the past few years. Progress has been made in many aspects such as the …
attention over the past few years. Progress has been made in many aspects such as the …
Metabolic engineering with power-law and linear-logarithmic systems
Metabolic Engineering aims to improve the performance of biotechnological processes
through rational manipulation rather than random mutagenesis of the organisms involved …
through rational manipulation rather than random mutagenesis of the organisms involved …
[HTML][HTML] Design of optimally constructed metabolic networks of minimal functionality
Background Metabolic engineering aims to design microorganisms that will generate a
product of interest at high yield. Thus, a variety of in silico modeling strategies has been …
product of interest at high yield. Thus, a variety of in silico modeling strategies has been …
Design principles and operating principles: the yin and yang of optimal functioning
EO Voit - Mathematical biosciences, 2003 - Elsevier
Metabolic engineering has as a goal the improvement of yield of desired products from
microorganisms and cell lines. This goal has traditionally been approached with …
microorganisms and cell lines. This goal has traditionally been approached with …