The elucidation of organism‐scale metabolic networks necessitates the development of
integrative methods to analyze and interpret the systemic properties of cellular metabolism …

Bioinformatics tools have facilitated the reconstruction and analysis of cellular metabolism of
various organisms based on information encoded in their genomes. Characterization of …

We focus on the application of constraint-based methodologies and, more specifically, flux
balance analysis in the field of metabolic engineering, and enumerate recent developments …

Metabolic engineering is an integrating methodology of analysis and synthesis for the
improvement of flux distribution of metabolic pathways in complicated bioprocesses, which …

Mathematical modeling is an essential tool for the comprehensive understanding of cell
metabolism and its interactions with the environmental and process conditions. Recent …

Secondary metabolites are not essential for the growth of microorganisms, but they play a
critical role in how microbes interact with their surroundings. In addition to this important …

Facility in the targeted manipulation of the genetic and metabolic composition of organisms,
combined with unprecedented computational power, is forging a niche for a new …

Metabolic engineering is not another form of classic manipulation of intermediary
metabolism; rather, it is the purposeful design of metabolic networks. The metabolic …

A recent article [1] addresses the important issue of network-based metabolic pathway
analysis. Various methods have been used to define systemic pathways for metabolic …

Abstract 13C‐Metabolic Flux Analysis (13C‐MFA) and Flux Balance Analysis (FBA) are
widely used to investigate the operation of biochemical networks in both biological and …