Abstract Treatment-resistant depression (TRD) presents major challenges for both patients
and clinicians. There is no universally accepted definition of TRD, but results from the US …

Managing patients with treatment-resistant depression (TRD) remains a major challenge for
the practicing physician. Depression is considered treatment-resistant when at least two …

Treatment-resistant depression (TRD) presents many challenges for both patients and
physicians. This review aims to evaluate the current status of the field of TRD and reflects the …

Treatment-resistant depression (TRD) is a common clinical occurrence among patients
treated for major depressive disorder. However, a clear consensus regarding the criteria …

The field of non-pharmacological therapies for treatment resistant depression (TRD) is
rapidly evolving and new somatic therapies are valuable options for patients who have …

AIM: To review evidence supporting pharmacological treatments for treatment-resistant
depression (TRD) and to discuss them according to personal clinical experience …

One in three adults with major depressive disorder (MDD) do not experience clinically
significant improvement after multiple sequential courses of antidepressants and have …

Background. The failure to achieve remission for patients with Major Depressive Disorder
(MDD) represents a major public health concern. Inadequately treated depression is …

Abstract Treatment-resistant depression (TRD) is a subset of Major Depressive Disorder
which does not respond to traditional and first-line therapeutic options. There are several …

Background Patients with major depression respond to antidepressant treatment, but 10%–
30% of them do not improve or show a partial response coupled with functional impairment …