Activation of glial cells and neuro–glial interactions are emerging as key mechanisms
underlying chronic pain. Accumulating evidence has implicated 3 types of glial cells in the …

Over the past few years, the control of pain exerted by glial cells has emerged as a
promising target against pathological pain. Indeed, changes in glial phenotypes have been …

During neuropathic pain, glial cells (mainly astrocytes and microglia) become activated and
initiate a series of signaling cascades that modulate pain processing at both spinal and …

Interactions between central glial cells and neurons in the pain circuitry are critical
contributors to the pathogenesis of chronic pain. In the central nervous system (CNS), two …

Within the past decade, there has been increasing recognition that glia are far more than
simply “housekeepers” for neurons. This review explores two recently recognized roles of …

Pain is classically viewed as being mediated solely by neurons, as are other sensory
phenomena. The discovery that spinal cord glia (microglia and astrocytes) amplify pain …

Management of chronic pain is a real challenge, and current treatments that focus on
blocking neurotransmission in the pain pathway have resulted in limited success. Activation …

Glia have emerged as key contributors to pathological and chronic pain mechanisms. On
activation, both astrocytes and microglia respond to and release a number of signalling …

Chronic pain, a pathological state, affects millions of people worldwide. Despite decades of
study on the neuronal processing of pain, mechanisms underlying the creation and …

In many clinical pain syndromes, painful sensations are greatly amplified so that normally
innocuous sensations, such as light touch or warmth, are perceived as pain. Presently …