High-density lipoprotein (HDL) dysfunction and the future of HDL

S Ertek - Current vascular pharmacology, 2018 - ingentaconnect.com
Although High Density Lipoprotein Cholesterol (HDL-C) levels are inversely proportional to
cardiovascular risk in many studies, recent pharmacological interventional studies with HDL …

HDL, atherosclerosis, and emerging therapies

A Hafiane, J Genest - Cholesterol, 2013 - Wiley Online Library
This review aims to provide an overview on the properties of high‐density lipoproteins
(HDLs) and their cardioprotective effects. Emergent HDL therapies will be presented in the …

Pharmacologic elevation of high-density lipoproteins: recent insights on mechanism of action and atherosclerosis protection

CD Meyers, ML Kashyap - Current Opinion in Cardiology, 2004 - journals.lww.com
An understanding of the atheroprotective mechanisms of HDL is essential for the rational
use of currently available drugs and directed development of new drugs. Increasing total …

High-density lipoprotein: epidemiology, metabolism, and antiatherogenic effects

PP Toth - Disease-a-month, 2001 - Elsevier
Conclusion HDL is clearly a functionally versatile molecule mediating a variety of molecular
processes protective against atherosclerosis. Mechanistic detail continues to greatly enrich …

The role of high-density lipoprotein (HDL) cholesterol in the prevention and treatment of coronary heart disease: expert group recommendations

FM Sacks - American Journal of Cardiology, 2002 - ajconline.org
Population studies from all parts of the world have consistently reported that a low plasma
level of high-density lipoprotein (HDL) cholesterol is a strong predictor of coronary heart …

Thematic review series: patient-oriented research. What have we learned about HDL metabolism from kinetics studies in humans?

S Rashid, BW Patterson, GF Lewis - Journal of lipid research, 2006 - ASBMB
Plasma measurements of lipids, lipoproteins, and apolipoproteins provide information on the
static levels of these fractions without providing key information on the dynamic fluxes of …

HDL cholesterol: physiology, pathophysiology, and management

JJ Link, A Rohatgi, JA de Lemos - Current problems in cardiology, 2007 - Elsevier
Numerous epidemiological studies have identified high-density lipoprotein cholesterol
(HDL) to be an independent risk factor for coronary heart disease (CHD). HDL is an …

Unraveling the complexities of the HDL lipidome1

A Kontush, M Lhomme, MJ Chapman - Journal of lipid research, 2013 - ASBMB
Plasma high density lipoproteins (HDL) are small, dense, protein-rich particles compared
with other lipoprotein classes; roughly half of total HDL mass is accounted for by lipid …

High-density lipoprotein and plaque regression: the good cholesterol gets even better

HM Dansky, EA Fisher - Circulation, 1999 - Am Heart Assoc
Primary and secondary prevention of coronary heart disease (CHD) has focused on
lowering the LDL fraction of blood lipids not only because of the strong epidemiological …

HDL in the 21st century: a multifunctional roadmap for future HDL research

A Rohatgi, M Westerterp, A Von Eckardstein… - Circulation, 2021 - Am Heart Assoc
Low high-density lipoprotein cholesterol (HDL-C) characterizes an atherogenic dyslipidemia
that reflects adverse lifestyle choices, impaired metabolism, and increased cardiovascular …