The “Obesity Paradox” and the use of NOAC

R Bottino, A Carbone, B Liccardo, P Golino… - … : From Pharmacology to …, 2021 - Springer
Obesity is a worldwide health problem at increasing incidence associated with high
morbidity and mortality. Although obesity increases patients' cardiovascular (CV) risk, more …

Efficacy and Safety of Direct Oral Anticoagulants (DOACs) in Morbidly Obese Patients

C Kalani, EA Henry, T Alexander, G Udeani, S Surani - Chest, 2018 - journal.chestnet.org
PURPOSE: There is a paucity of clinical data evaluating anticoagulation with the direct oral
anticoagulants (DOACs) in morbidly obese patients. We sought to examine the efficacy and …

[HTML][HTML] Effectiveness of direct oral anticoagulants in obese adults with atrial fibrillation: a systematic review of systematic reviews and meta-analysis

F Shaikh, R Wynne, RL Castelino, SC Inglis… - Frontiers in …, 2021 - frontiersin.org
Background: Atrial Fibrillation (AF) is the most common sustained cardiac arrhythmia.
Obesity is an independent risk factor for AF. Anticoagulants have been strongly …

Evaluation of the efficacy of direct oral anticoagulants (DOACs) in comparison to warfarin in morbidly obese patients

C Kalani, E Awudi, T Alexander, G Udeani… - Hospital …, 2019 - Taylor & Francis
Purpose: There is limited clinical data evaluating anticoagulation with the direct oral
anticoagulants (DOACs) in morbidly obese patients. We sought to examine the efficacy in …

[HTML][HTML] Low body weight and prescribing DOACs in atrial fibrillation

FWA Verheugt - Journal of the American College of Cardiology, 2019 - jacc.org
Oral anticoagulation (OAC) is the cornerstone for the prevention of stroke in most patients
with atrial fibrillation (AF). The traditional treatment consists of warfarin, but direct oral …

The impact of underweight and obesity on outcomes in anticoagulated patients with atrial fibrillation: a systematic review and meta‐analysis on the obesity paradox

M Grymonprez, A Capiau, TL De Backer… - Clinical …, 2021 - Wiley Online Library
Although obesity is associated with the development and progression of atrial fibrillation
(AF), an obesity paradox may be present, illustrated by seemingly protective effects of …

Ischemic Stroke in Patients with Elevated Body Mass Index while on Novel Anticoagulants: A case series report (P1. 059)

H Kamal, K Smith, A Mowla, P Shirani, R Sawyer Jr… - Neurology, 2015 - AAN Enterprises
BACKGROUND: Atrial fibrillation if left untreated increases the risk of stroke by five fold.
Novel oral anticoagulants (NOAC) are being increasingly used as a convenient alternative …

Efficacy and safety of direct oral anticoagulants for atrial fibrillation across body mass index categories

RM Kaplan, Y Tanaka, RS Passman… - Journal of the …, 2020 - Am Heart Assoc
Background Direct‐acting oral anticoagulants are now the preferred method of
anticoagulation in patients with atrial fibrillation. Limited data on efficacy and safety of these …

Association between body mass index and long-term clinical outcomes in patients with non-valvular atrial fibrillation taking oral anticoagulants

M Nezu, S Ueda, K Uchida, F Sakakibara, N Kinjo… - Heart and Vessels, 2023 - Springer
Background and aims The association between body mass index (BMI) and clinical
outcomes of patients with non-valvular atrial fibrillation (NVAF) taking oral anticoagulants …

Rivaroxaban versus warfarin for management of obese African Americans with non-valvular atrial fibrillation or venous thromboembolism: a retrospective cohort …

OS Costa, J Beyer-Westendorf… - Clinical and Applied …, 2020 - journals.sagepub.com
African Americans (AAs) and obese individuals have increased thrombotic risk. This study
evaluated the effectiveness and safety of rivaroxaban versus warfarin in obese, AAs with …