DREADDing the lateral habenula: a review of methodological approaches for studying lateral habenula function

SG Nair, NS Strand, JF Neumaier - Brain research, 2013 - Elsevier
The lateral habenula (LHb) is part of the habenular complex in the dorsal diencephalon. The
LHb is an important regulator of several neurotransmitter systems in the midbrain; …

Disentangling neuronal inhibition and inhibitory pathways in the lateral habenula

JF Webster, R Vroman, K Balueva, P Wulff, S Sakata… - Scientific reports, 2020 - nature.com
The lateral habenula (LHb) is hyperactive in depression, and thus potentiating inhibition of
this structure makes an interesting target for future antidepressant therapies. However, the …

The role of the habenula in drug addiction

KM Velasquez, DL Molfese, R Salas - Frontiers in human …, 2014 - frontiersin.org
Interest in the habenula has greatly increased in recent years. The habenula is a small brain
structure located posterior to the thalamus and adjacent to the third ventricle. Despite its …

The role of the habenula in the transition from reward to misery in substance use and mood disorders

A Batalla, JR Homberg, TV Lipina, G Sescousse… - Neuroscience & …, 2017 - Elsevier
The habenula (Hb) is an evolutionary well-conserved structure located in the epithalamus.
The Hb receives inputs from the septum, basal ganglia, hypothalamus, anterior cingulate …

A GABAergic cell type in the lateral habenula links hypothalamic homeostatic and midbrain motivation circuits with sex steroid signaling

L Zhang, VS Hernández, JD Swinny, AK Verma… - Translational …, 2018 - nature.com
The lateral habenula (LHb) has a key role in integrating a variety of neural circuits
associated with reward and aversive behaviors. There is limited information about how the …

Input to the lateral habenula from the basal ganglia is excitatory, aversive, and suppressed by serotonin

SJ Shabel, CD Proulx, A Trias, RT Murphy, R Malinow - Neuron, 2012 - cell.com
The lateral habenula (LHb) has recently been identified as a key regulator of the reward
system by driving inhibition onto dopaminergic neurons. However, the nature and potential …

The role of the medial habenula cholinergic system in addiction and emotion-associated behaviors

HW Lee, SH Yang, JY Kim, H Kim - Frontiers in psychiatry, 2019 - frontiersin.org
The habenula is a complex nucleus composed of lateral and medial subnuclei, which
connect between the limbic forebrain and midbrain. Over the past few years, the lateral …

Translating the habenula—from rodents to humans

LJ Boulos, E Darcq, BL Kieffer - Biological psychiatry, 2017 - Elsevier
The habenula (Hb) is a central structure connecting forebrain to midbrain regions. This
microstructure regulates monoaminergic systems, notably dopamine and serotonin, and …

A major role for the lateral habenula in depressive illness: physiologic and molecular mechanisms

PW Gold, B Kadriu - Frontiers in Psychiatry, 2019 - frontiersin.org
Emerging preclinical and clinical evidence indicate that the lateral habenula plays a major
role in the pathophysiology of depressive illness. Aberrant increases in neuronal activity in …

The medial habenula: still neglected

H Viswanath, AQ Carter, PR Baldwin… - Frontiers in human …, 2014 - frontiersin.org
The habenula is a small, bilateral brain structure located at the dorsal end of the
diencephalon. This structure sends projections to the dopaminergic striatum and receives …