In the developing nervous system, nerve cells and axons respond to various attractive and
repulsive guidance cues while traveling to their final destination. Netrins are bifunctional …

Proper patterning of the nervous system requires that developing axons find appropriate
postsynaptic partners; this entails microns to meters of extension through an extracellular …

Although netrins are an important family of neuronal guidance proteins, intracellular
mechanisms that mediate netrin function are not well understood. Here we show that netrin …

During the development of the nervous system, neurons respond to the coordinated action
of a variety of attractive and repulsive signals from the embryonic environment. Netrins form …

The canonical model for netrin1 function proposed that it acted as a long-range chemotropic
axon guidance cue. In the developing spinal cord, floor-plate (FP)-derived netrin1 was …

The Netrin family of extracellular ligands and their receptors were the first identified
signaling pathway regulating axon guidance. Subsequent work across model systems has …

The netrins are a small but highly conserved family of axonal guidance signals found
throughout the animal kingdom. This sequence conservation was used to isolated cDNAs for …

The proper regulation of temporal and spatial expression of the axon guidance cues and
their receptors is critical for the normal wiring of nervous system during development …

Netrins are a family of proteins that direct cell and axon migration during development.
Three secreted netrins (netrin-1,-3 and-4) have been identified in mammals, in addition to …

Recent advances highlight the versatility and complexity of this highly conserved axon and
cell migration guidance system. Characterization of netrin mutant phenotypes in worm, fly …