Previous tracer studies have shown segmental outflow in the trabecular meshwork (TM) and
along the inner wall (IW) of Schlemm's canal (SC). Whether segmental outflow is conserved …

All aqueous humor draining through the conventional outflow pathway must cross the
endothelium of Schlemm's canal (SC), likely by passing through micron-sized …

The site of outflow resistance leading to elevated intraocular pressure in primary open-angle
glaucoma is believed to be located in the region of Schlemm's canal inner wall endothelium …

We have recently developed a technique for constant pressure perfusion of the aqueous
outflow pathway of the eye. Our preliminary studies, conducted in the calf eye, show …

Current understanding of conventional outflow dysfunction in... : Current Opinion in
Ophthalmology Current understanding of conventional outflow dysfunction in glaucoma …

Glaucoma is a leading cause of blindness worldwide and results from damage to the optic
nerve. Currently, intraocular pressure is the only treatable risk factor. Changes in aqueous …

purpose. To determine whether preferential pathways exist within the human trabecular
meshwork, pigmented and nonpigmented regions adjacent to and between collector …

Purpose: Aqueous humor filtration in the trabecular meshwork is believed to be non-uniform
or “segmental” such that only a fraction of trabecular meshwork is filtration-active at any …

In glaucoma, lowered intraocular pressure (IOP) confers neuroprotection. Elevated IOP
characterizes glaucoma and arises from impaired aqueous humor (AH) outflow. Increased …

The main and only modifiable risk factor in glaucoma, the group of usually late onset
progressive and irreversible blinding optic neuropathies, is elevated intraocular pressure …