Extracellular factors that inhibit axon growth and intrinsic factors that promote it affect neural
regeneration. Therapies targeting any single gene have not yet simultaneously optimized …

Chondroitin sulfate proteoglycans (CSPGs) are up‐regulated following spinal cord injury
and are partly responsible for failed regeneration. Experimental paradigms in vivo that …

Axons in the peripheral nervous system can regenerate after injury, whereas axons in the
central nervous system (CNS) do not readily regenerate. Intrinsic regenerating capacity and …

The presence of numerous axon-inhibitory molecules limits the capacity of injured neurons
in the adult mammalian central nervous system (CNS) to regenerate damaged axons …

Background There is currently no effective treatment for promoting regeneration of injured
nerves in patients who have sustained injury to the central nervous system such as spinal …

Spinal cord injury (SCI) causes permanent debilitation due to the inability of axons to grow
through established scars. Both the sugar chains and core proteins of chondroitin sulfate …

Chondroitin sulphate proteoglycans (CSPGs) are up‐regulated in the CNS after injury and
inhibit axon regeneration mainly through their glycosaminoglycan (CS‐GAG) chains. We …

Neurons in the adult CNS do not spontaneously regenerate after injuries. The
glycosaminoglycan keratan sulfate is induced after spinal cord injury, but its biological …

Axon regeneration in the central nervous system is limited both by inhibitory extracellular
cues and by an intrinsically low capacity for axon growth in some CNS populations …

After injury to the adult central nervous system, levels of extracellular matrix molecules
increase at the injury site and may inhibit the repair of injured axons. Among these …