Overexpression of ATP-dependent efflux pump P-glycoprotein (P-gp) is the main cause of
multidrug resistance (MDR) and chemotherapy failure in cancer treatment. Inhibition of P-gp …

Multidrug resistance (MDR) to chemotherapeutic drugs is the main cause of chemotherapy
failure in cancer treatment, and it generally results from expression of ATP-dependent efflux …

Purpose H1 is a novel derivative of tetrandrine (Tet). Here we investigate the ability of H1 to
reverse P-glycoprotein (Pgp)-mediated multidrug resistance (MDR) and its mechanisms …

Tetrandrine (Tet) is a potent inhibitor that reverses P‑glycoprotein‑mediated multidrug
resistance (MDR). A number of novel 5‑substituted tetrandrine derivatives were synthesized …

Targeted inhibition of a drug efflux transporter P-glycoprotein (P-gp) is an important strategy
to reverse multidrug resistance in cancer chemotherapy. In this study, a rationally structural …

Background Multidrug efflux transporter P-glycoprotein (P-gp) is highly expressed on
membrane of tumor cells and is implicated in resistance to tumor chemotherapy. HZ08 is …

P-glycoprotein (P-gp), a member of ATP-Binding Cassette transporter superfamily, can expel
a variety of anti-cancer drugs so that it impairs the effect of cancer chemotherapy and results …

Enhanced drug efflux through ATP-binding cassette transporters, particularly P-glycoprotein
(P-gp), is a key mechanism underlying multidrug resistance (MDR). In the present study, we …

The overexpression of ABC transporters is a common reason for multidrug resistance (MDR)
in cancer cells. In this study, we found that the isoquinoline alkaloids tetrandrine and …

This study investigated the reversal effect of isotetrandrine, an isoquinoline alkaloid
extracted from Caulis mahoniae, on P-glycoprotein-mediated multidrug resistance in human …