Macrophages are cells of the innate immune system that are resident in all tissues, including
metabolic organs such as the liver and adipose tissue (AT). Because of their phenotypic …

Macrophages play a key role in defending against foreign pathogens, healing wounds, and
regulating tissue homeostasis. Driving this versatility is their phenotypic plasticity, which …

A multitude of micro-and nanoparticles have been developed to improve the delivery of
systemically administered pharmaceuticals, which are subject to a number of biological …

Hepatic macrophage populations include different types of cells with plastic properties that
can differentiate into diverse phenotypes to modulate their properties in response to different …

Obesity leads to an increased risk for type 2 diabetes, heart disease, stroke, and cancer. The
causal link between obesity and these pathologies has recently been identified as chronic …

Macrophage is the key innate immune effector in first-line defense against the pathogens,
and can be polarized into different phenotypes to regulate a variety of immunological …

Biomimetic nanoparticles aim to effectively emulate the behavior of either cells or exosomes.
Leukocyte-based biomimetic nanoparticles, for instance, incorporate cell membrane …

Liposomes are spherical-enclosed membrane vesicles mainly constructed with lipids. Lipid
nanoparticles are loaded with therapeutics and may not contain an enclosed bilayer. The …

Tissue repair and regeneration is a complex process. Our bodies have an excellent capacity
to regenerate damaged tissues in many situations. However, tissue healing is impaired in …

Macrophages are innate immune cells with great phenotypic plasticity, which allows them to
regulate an array of physiological processes such as host defense, tissue repair, and …