Abstract Background and Aim: The excretion of cholesterol from the liver is regulated by the
ATP‐binding cassette transporter ABCG8. A common genetic polymorphism D19H of …

Abstract Background and Aim: Gallstone formation is characterized by the abnormal
regulation of cholesterol trafficking and solubilization. The prevalence of gallstone disease …

Cholesterol gallstone disease is one of the most common digestive diseases, with an overall
prevalence of 10–20%. Although a common and economically-relevant problem in …

Background Adenosine triphosphate-binding cassette (ABC) transporters ABCG5 and
ABCG8 are sterol export pumps regulating biliary cholesterol excretion. The formation of …

Background: Gallbladder cancer (GBC) usually arises against the background of gallstone
disease, which may be causatively related to supersaturation of cholesterol in bile. An …

Abstract ATP Binding Cassette Transporter A4 (ABCB4) is a sterol export pump that
regulates excretion of biliary cholesterol. We tested association between ABCB4 …

BACKGROUND: Supersaturation of bile with cholesterol is a primary step in the formation of
cholesterol gallstones. ATP binding cassette (ABC) G5 and G8 play an important role in …

Background Gallstone disease is associated with p. D19H of ABCG8 as well as alterations
of cholesterol and bile acid metabolism. However, molecular mechanisms have not been …

Background Gallstones are abnormal masses caused by impaired metabolism of
cholesterol, bilirubin, or bile salts in the gallbladder or biliary tract. ATP-binding cassette …

BACKGROUND: The role of ABCG5 and ABCG8 genes in the determination of plasma lipid
levels is currently under intensive investigation. The aim of this study was to evaluate …