Neural tube defects (NTDs) are considered to be a complex genetic disorder, although the
identity of the genetic factors remains largely unknown. Mouse model studies suggest a …

Extensive studies that have sought causative mutation (s) for neural tube defects (NTDs)
have yielded limited positive findings to date. One possible reason for this is that many …

Neural tube defects (NTDs) are among the commonest and most severe forms of
developmental defect, characterized by disruption of the early embryonic events of central …

Neural Tube Defects (NTDs) are congenital malformations that involve failure of the neural
tube closure during the early phases of development at any level of the rostro‐caudal axis …

Background Mouse homozygous mutants in Wnt/planar cell polarity (PCP) pathway genes
have been shown to cause neural tube defects (NTDs) through the disruption of normal …

BACKGROUND Neural tube defects (NTDs), including anencephaly and spina bifida, have
a complex etiology. Defects in the planar cell polarity (PCP) signaling pathway have been …

Neural tube defects (NTDs), including spina bifida and anencephaly, represent the most
severe and common malformations of the central nervous system affecting 0.7–3 per 1000 …

Neural tube defect disorders are developmental diseases that originate from an incomplete
closure of the neural tube during embryogenesis. Despite high prevalence—1 out of 3000 …

A variety of human birth defects originate in failure of closure of the embryonic neural tube.
The genetic cause of the most common nonsyndromic defects, spina bifida (SB) or …

Background Neural Tube Defects (NTD) are a common class of birth defects that occur in
approximately 1 in 1000 live births. Both genetic and nongenetic factors are involved in the …