[HTML][HTML] Pathogenic role of IL-17-producing immune cells in obesity, and related inflammatory diseases

M Chehimi, H Vidal, A Eljaafari - Journal of clinical medicine, 2017 - mdpi.com
Obesity is associated with low-grade chronic inflammation. Indeed, adipose tissues (AT) in
obese individuals are the former site of progressive infiltration by pro-inflammatory immune …

IL-17 in obesity and adipogenesis

M Ahmed, SL Gaffen - Cytokine & growth factor reviews, 2010 - Elsevier
The pro-inflammatory cytokine interleukin (IL)-17 (also known as IL-17) has been associated
with induction of tissue inflammation. Obese individuals exhibit many symptoms of chronic …

IL-17 inhibits adipogenesis in part via C/EBPα, PPARγ and Krüppel-like factors

M Ahmed, SL Gaffen - Cytokine, 2013 - Elsevier
IL-17 is an inflammatory cytokine associated with anti-microbial host defense and
pathogenesis of autoimmune diseases. Obesity is considered to be an inflammatory …

IL-17 regulates adipogenesis, glucose homeostasis, and obesity

LA Zúñiga, WJ Shen, B Joyce-Shaikh… - The Journal of …, 2010 - journals.aai.org
Inflammatory mediators have the potential to impact a surprising range of diseases,
including obesity and its associated metabolic syndrome. In this paper, we show that the …

T cell–derived IL-22 amplifies IL-1β–driven inflammation in human adipose tissue: Relevance to obesity and type 2 diabetes

E Dalmas, N Venteclef, C Caer, C Poitou, I Cremer… - Diabetes, 2014 - Am Diabetes Assoc
Proinflammatory cytokines are critically involved in the alteration of adipose tissue biology
leading to deterioration of glucose homeostasis in obesity. Here we show a pronounced …

Interleukin-17A inhibits adipocyte differentiation in human mesenchymal stem cells and regulates pro-inflammatory responses in adipocytes

JH Shin, DW Shin, M Noh - Biochemical pharmacology, 2009 - Elsevier
The immune system is closely linked to human metabolic diseases. Serum levels of IL-6
increase with obesity and insulin resistance. Not only does IL-6 decrease the insulin …

Adipose tissue–derived stem cells from obese subjects contribute to inflammation and reduced insulin response in adipocytes through differential regulation of the Th1 …

A Eljaafari, M Robert, M Chehimi, S Chanon… - Diabetes, 2015 - Am Diabetes Assoc
Obesity, through low-grade inflammation, can drive insulin resistance and type 2 diabetes.
While infiltration of adipose tissue (AT) with mononuclear cells (MNCs) is well established in …

Obesity predisposes to Th17 bias

S Winer, G Paltser, Y Chan, H Tsui… - European journal of …, 2009 - Wiley Online Library
Obesity is associated with numerous inflammatory conditions including atherosclerosis,
autoimmune disease and cancer. Although the precise mechanisms are unknown, obesity …

[HTML][HTML] Adipose tissue dendritic cells enhances inflammation by prompting the generation of Th17 cells

Y Chen, J Tian, X Tian, X Tang, K Rui, J Tong, L Lu… - PloS one, 2014 - journals.plos.org
Background Obesity has become a global challenge for public health. It has been reported
that obesity is associated with chronic inflammation. However, the mechanism for the …

Stromal cells maintain immune cell homeostasis in adipose tissue via production of interleukin-33

T Mahlakõiv, AL Flamar, LK Johnston, S Moriyama… - Science …, 2019 - science.org
Obesity is driven by chronic low-grade inflammation resulting from dysregulated immune cell
accumulation and function in white adipose tissue (WAT). Interleukin-33 (IL-33) is a key …