Simple Summary Tricyclic antidepressants (TCAs) are old and known therapeutic agents
whose good safety profile makes them good candidates for drug repurposing. As the …

Background: Chemotherapy-induced peripheral neuropathy (CIPN) is a painful condition,
experienced by patients undergoing chemotherapy with some specific drugs, such as …

Chemotherapy-induced peripheral neuropathy (CIPN) is one of the most disabling and
demoralizing problems that arise for cancer survivors. When investigating symptoms of …

Antidepressant drugs have been widely used for many years to treat neuropathic pain,
despite the rationale for their use was still unclear. We review recent insights into their …

5-HT3 receptor antagonists corresponding to ondansetron, granisetron, tropisetron, and
palonosetron are clinically accustomed to treating nausea and emesis in chemotherapy …

Painful neuropathy is a major side-effect limiting cancer chemotherapy. Therefore, novel
strategies are required to suppress the neuropathic effects of anticancer drugs without …

Abstract Background and Aims The expanding use of chemotherapy in curative cancer
treatment has simultaneously resulted in a substantial and growing cohort of cancer …

Neither pain, nor depression exist as independent phenomena per se, they are highly
subjective inner states, formed by our brain and built on the bases of our experiences …

The role of tricyclic antidepressants (TCAs) in the treatment of cancer pain is of growing
interest. Various studies, all but one of them open, have suggested that TCAs are effective …

Cancer, a chronic disease characterized by uncontrolled cell development, kills millions of
people globally. The WHO reported over 10 million cancer deaths in 2020. Anticancer …