Hepatotoxicity induced by acetaminophen (APAP)‐overdose is a major concern in clinical
practice. In the present work, the detoxifying effect of irbesartan (Irb) on the APAP‐induced …

Apigenin (API) is a natural flavonoid abundant in fruits and vegetables. The present study
was undertaken to evaluate the effect of protein malnutrition (PMN) on acetaminophen …

To explore the action time and molecular mechanism underlying the effect of
acetaminophen (APAP) on liver injury. APAP was used to establish drug-induced liver injury …

Acetaminophen (APAP) overdose is a common cause of acute liver failure, and beta‐
blockers are commonly used drugs in clinical practice. This study aimed to evaluate the …

A water-soluble acacetin prodrug has been synthesized and reported by our group
previously. Acetaminophen (APAP) overdose is a leading cause of acute liver injury. We …

Background Acetaminophen (APAP) overdose induces severe oxidative stress followed by
hepatocyte apoptosis/necrosis. Previous studies have indicated that endoplasmic reticulum …

Background. Excessive acetaminophen (APAP) use can lead to acute liver injury (ALI) by
inducing endoplasmic reticulum stress (ERS). We previously found that pretreatment with …

Acetaminophen (APAP) is known to cause acute liver injury and acute liver failure in
Western countries. This study investigates the protective role of farnesol (FAR)(C15H26O), a …

Amlexanox, a clinically approved small-molecule therapeutic presently used to treat allergic
rhinitis, ulcer, and asthma, is an inhibitor of the noncanonical IkB kinase-ε (IKKε) and TANK …

Drug‐induced liver injury (DILI) is a frequent cause responsible for acute liver failure (ALF).
Acetaminophen (APAP) is a known hepatotoxin predictably causing intrinsic DILI. At high …