Acetaminophen (APAP) stands as the predominant contributor to drug-induced liver injury
(DILI), and limited options are available. β-Arrestin1 (ARRB1) is involved in numerous liver …

Overdose of acetaminophen (APAP) is the main reason for acute liver failure. Oxidative
stress is associated with hepatotoxicity caused by APAP. Betaine is a methyl donor and S …

Acetaminophen (APAP) is a common antipyretic and analgesic drug, but its overdose can
induce acute liver failure with lack of effective therapies. Hesperetin, a dihydrogen flavonoid …

Acetaminophen (APAP) hepatotoxicity is a serious public health problem in western
countries. Current treatment options for APAP poisoning are limited and novel therapeutic …

Aims Acetaminophen (APAP) overdose leads to severe hepatotoxicity. Isoquercitrin
exhibited potential hepatoprotective effect in our previous study. The present investigation …

Metabolic activation and oxidant stress are key events in the pathophysiology of
acetaminophen (APAP) hepatotoxicity. The initial mitochondrial oxidative stress triggered by …

Acetaminophen (APAP) overdose is one of the most common causes of drug‐induced acute
liver failure in humans. To investigate the hepatoprotective effect of salvianolic acid C (SAC) …

Simple Summary Acetaminophen overdose causes acute liver injury by excessive oxidative
stress. The present study examines the mechanisms underlying the protective effect of …

Acetaminophen or paracetamol (APAP) overdose is a common cause of liver injury.
Silymarin (SLM) is a hepatoprotective agent widely used for treating liver injury of different …

Paracetamol-induced hepatotoxicity (APAP) causes severe damage that may be
irreversible. Understanding the evolution of liver injury caused by overdose of the drug is …