ARRB1 downregulates acetaminophen-induced hepatoxicity through binding to p-eIF2α to inhibit ER stress signaling
Y Luo, Y Lei, H Zhou, Y Chen, H Liu, J Jiang… - Cell Biology and …, 2024 - Springer
Acetaminophen (APAP) stands as the predominant contributor to drug-induced liver injury
(DILI), and limited options are available. β-Arrestin1 (ARRB1) is involved in numerous liver …
(DILI), and limited options are available. β-Arrestin1 (ARRB1) is involved in numerous liver …
Upregulation of Nrf2-related cytoprotective genes expression by acetaminophen-induced acute hepatotoxicity in mice and the protective role of betaine
Overdose of acetaminophen (APAP) is the main reason for acute liver failure. Oxidative
stress is associated with hepatotoxicity caused by APAP. Betaine is a methyl donor and S …
stress is associated with hepatotoxicity caused by APAP. Betaine is a methyl donor and S …
Hesperetin attenuated acetaminophen-induced hepatotoxicity by inhibiting hepatocyte necrosis and apoptosis, oxidative stress and inflammatory response via …
J Wan, G Kuang, L Zhang, R Jiang, Y Chen… - International …, 2020 - Elsevier
Acetaminophen (APAP) is a common antipyretic and analgesic drug, but its overdose can
induce acute liver failure with lack of effective therapies. Hesperetin, a dihydrogen flavonoid …
induce acute liver failure with lack of effective therapies. Hesperetin, a dihydrogen flavonoid …
Benzyl alcohol protects against acetaminophen hepatotoxicity by inhibiting cytochrome P450 enzymes but causes mitochondrial dysfunction and cell death at higher …
Acetaminophen (APAP) hepatotoxicity is a serious public health problem in western
countries. Current treatment options for APAP poisoning are limited and novel therapeutic …
countries. Current treatment options for APAP poisoning are limited and novel therapeutic …
Hepatoprotective effect of isoquercitrin against acetaminophen-induced liver injury
W Xie, M Wang, C Chen, X Zhang, MF Melzig - Life sciences, 2016 - Elsevier
Aims Acetaminophen (APAP) overdose leads to severe hepatotoxicity. Isoquercitrin
exhibited potential hepatoprotective effect in our previous study. The present investigation …
exhibited potential hepatoprotective effect in our previous study. The present investigation …
Inhibitor of apoptosis signal-regulating kinase 1 protects against acetaminophen-induced liver injury
Y Xie, A Ramachandran, DG Breckenridge… - Toxicology and applied …, 2015 - Elsevier
Metabolic activation and oxidant stress are key events in the pathophysiology of
acetaminophen (APAP) hepatotoxicity. The initial mitochondrial oxidative stress triggered by …
acetaminophen (APAP) hepatotoxicity. The initial mitochondrial oxidative stress triggered by …
Salvianolic acid C against acetaminophen‐induced acute liver injury by attenuating inflammation, oxidative stress, and apoptosis through inhibition of the Keap1/Nrf2 …
CT Wu, JS Deng, WC Huang, PC Shieh… - Oxidative Medicine …, 2019 - Wiley Online Library
Acetaminophen (APAP) overdose is one of the most common causes of drug‐induced acute
liver failure in humans. To investigate the hepatoprotective effect of salvianolic acid C (SAC) …
liver failure in humans. To investigate the hepatoprotective effect of salvianolic acid C (SAC) …
Role of NADPH oxidase-derived ROS-mediated IL-6/STAT3 and MAPK/NF-κB signaling pathways in protective effect of corilagin against acetaminophen-induced liver …
FC Liu, HC Lee, CC Liao, AH Chou, HP Yu - Biology, 2023 - mdpi.com
Simple Summary Acetaminophen overdose causes acute liver injury by excessive oxidative
stress. The present study examines the mechanisms underlying the protective effect of …
stress. The present study examines the mechanisms underlying the protective effect of …
Silymarin prevents acetaminophen-induced hepatotoxicity in mice
Z Papackova, M Heczkova, H Dankova, E Sticova… - PloS one, 2018 - journals.plos.org
Acetaminophen or paracetamol (APAP) overdose is a common cause of liver injury.
Silymarin (SLM) is a hepatoprotective agent widely used for treating liver injury of different …
Silymarin (SLM) is a hepatoprotective agent widely used for treating liver injury of different …
Temporal analysis of paracetamol-induced hepatotoxicity
AM Coelho, IF Queiroz, WG Lima… - Drug and Chemical …, 2023 - Taylor & Francis
Paracetamol-induced hepatotoxicity (APAP) causes severe damage that may be
irreversible. Understanding the evolution of liver injury caused by overdose of the drug is …
irreversible. Understanding the evolution of liver injury caused by overdose of the drug is …