Neuronal p38 MAPK signalling: an emerging regulator of cell fate and function in the nervous system

K Takeda, H Ichijo - Genes to Cells, 2002 - Wiley Online Library
p38 mitogen‐activated protein kinases (MAPKs), together with extracellular signal‐regulated
kinases (ERKs) and c‐Jun N‐terminal kinases (JNKs), constitute the MAPK family. Multiple …

Mechanisms and functions of p38 MAPK signalling

A Cuadrado, AR Nebreda - Biochemical journal, 2010 - portlandpress.com
The p38 MAPK (mitogen-activated protein kinase) signalling pathway allows cells to
interpret a wide range of external signals and respond appropriately by generating a …

Functions of p38 MAP kinases in the central nervous system

PR Asih, E Prikas, K Stefanoska, ARP Tan… - Frontiers in molecular …, 2020 - frontiersin.org
Mitogen-activated protein (MAP) kinases are a central component in signaling networks in a
multitude of mammalian cell types. This review covers recent advances on specific functions …

Mitogen-activated protein kinases in apoptosis regulation

T Wada, JM Penninger - Oncogene, 2004 - nature.com
Cells are continuously exposed to a variety of environmental stresses and have to decide 'to
be or not to be'depending on the types and strength of stress. Among the many signaling …

Context specificity of stress-activated mitogen-activated protein (MAP) kinase signaling: the story as told by Caenorhabditis elegans

MG Andrusiak, Y Jin - Journal of Biological Chemistry, 2016 - ASBMB
Stress-associated p38 and JNK mitogen-activated protein (MAP) kinase signaling cascades
trigger specific cellular responses and are involved in multiple disease states. At the root of …

Involvement of p38 MAPK in synaptic function and dysfunction

C Falcicchia, F Tozzi, O Arancio, DM Watterson… - International journal of …, 2020 - mdpi.com
Many studies have revealed a central role of p38 MAPK in neuronal plasticity and the
regulation of long-term changes in synaptic efficacy, such as long-term potentiation (LTP) …

JNK and p38 stresskinases—degenerative effectors of signal-transduction-cascades in the nervous system

K Mielke, T Herdegen - Progress in neurobiology, 2000 - Elsevier
The c-Jun N-terminal kinases (JNKs, also called stress activated protein kinases, SAPKs)
and p38 kinases constitute together with extracellular signal-regulated kinases (ERKs) the …

The role of p38 MAPK and its substrates in neuronal plasticity and neurodegenerative disease

SAL Corrêa, KL Eales - Journal of signal transduction, 2012 - Wiley Online Library
A significant amount of evidence suggests that the p38‐mitogen‐activated protein kinase
(MAPK) signalling cascade plays a crucial role in synaptic plasticity and in …

p38MAPK: stress responses from molecular mechanisms to therapeutics

LR Coulthard, DE White, DL Jones… - Trends in molecular …, 2009 - cell.com
The p38 MAPK protein kinases affect a variety of intracellular responses, with well-
recognized roles in inflammation, cell-cycle regulation, cell death, development …

[HTML][HTML] Non-classical p38 map kinase functions: cell cycle checkpoints and survival

TM Thornton, M Rincon - International journal of biological …, 2009 - ncbi.nlm.nih.gov
The p38 MAPK kinase pathway is activated in response to a wide range of cellular stress
stimuli and cytokines. Our understanding of the important functions of p38 MAPK in the …