Activated glia induce neuron death via MAP kinase signaling pathways involving JNK and p38
Z Xie, CJ Smith, LJ Van Eldik - Glia, 2004 - Wiley Online Library
Chronic glial activation in neurodegenerative diseases contributes to neuronal dysfunction
and neuron loss through production of neuroinflammatory molecules. However, the …
and neuron loss through production of neuroinflammatory molecules. However, the …
Inhibition of neuronal p38α, but not p38β MAPK, provides neuroprotection against three different neurotoxic insults
B Xing, AD Bachstetter, LJ Van Eldik - Journal of Molecular Neuroscience, 2015 - Springer
The p38 mitogen-activated protein kinase (MAPK) pathway plays a key role in pathological
glial activation and neuroinflammatory responses. Our previous studies demonstrated that …
glial activation and neuroinflammatory responses. Our previous studies demonstrated that …
MAP kinase pathways
DK Morrison - Cold Spring Harbor perspectives in …, 2012 - cshperspectives.cshlp.org
MAP Kinase Pathways Cold Spring Harbor Perspectives in Biology Skip to main page content
HOME ABOUT SUBJECT COLLECTIONS ARCHIVE SUBSCRIBE ADVERTISE ALERTS …
HOME ABOUT SUBJECT COLLECTIONS ARCHIVE SUBSCRIBE ADVERTISE ALERTS …
Microglial p38α MAPK is critical for LPS-induced neuron degeneration, through a mechanism involving TNFα
B Xing, AD Bachstetter, LJ Van Eldik - Molecular neurodegeneration, 2011 - Springer
Background The p38α MAPK isoform is a well-established therapeutic target in peripheral
inflammatory diseases, but the importance of this kinase in pathological microglial activation …
inflammatory diseases, but the importance of this kinase in pathological microglial activation …
Distinct requirements for p38α and c-Jun N-terminal kinase stress-activated protein kinases in different forms of apoptotic neuronal death
J Cao, MM Semenova, VT Solovyan, J Han… - Journal of Biological …, 2004 - ASBMB
The stress-activated protein kinases c-Jun-activated kinase (JNK) and p38 are implicated in
neuronal apoptosis. Early studies in cell lines suggested a requirement for both in the …
neuronal apoptosis. Early studies in cell lines suggested a requirement for both in the …
The p38MAPK-MK2 Signaling Axis as a Critical Link Between Inflammation and Synaptic Transmission
E Beamer, SAL Corrêa - Frontiers in cell and developmental biology, 2021 - frontiersin.org
p38 is a mitogen-activated protein kinase (MAPK), that responds primarily to stress stimuli.
p38 has a number of targets for phosphorylation, including MAPK-activated protein kinase 2 …
p38 has a number of targets for phosphorylation, including MAPK-activated protein kinase 2 …
Isolation and characterization of pmk-(1–3): three p38 homologs in Caenorhabditis elegans
K Berman, J McKay, L Avery, M Cobb - Molecular cell biology research …, 2001 - Elsevier
p38, a member of the mitogen-activated protein kinase (MAPK) superfamily, is activated in
response to a variety of cellular stresses and ligands. Since the genome of the nematode C …
response to a variety of cellular stresses and ligands. Since the genome of the nematode C …
Atypical p38 signaling, activation, and implications for disease
JC Burton, W Antoniades, J Okalova, MM Roos… - International Journal of …, 2021 - mdpi.com
The mitogen-activated protein kinase (MAPK) p38 is an essential family of kinases,
regulating responses to environmental stress and inflammation. There is an ever-increasing …
regulating responses to environmental stress and inflammation. There is an ever-increasing …
Cyclic AMP‐induced neuronal differentiation via activation of p38 mitogen‐activated protein kinase
TO Hansen, JF Rehfeld… - Journal of …, 2000 - Wiley Online Library
The p38 mitogen‐activated protein kinase (MAPK) pathway mediates cellular responses to
inflammatory cytokines and environmental stress, but recent studies have indicated that p38 …
inflammatory cytokines and environmental stress, but recent studies have indicated that p38 …
New insights into the p38γ and p38δ MAPK pathways
A Risco, A Cuenda - Journal of signal transduction, 2012 - Wiley Online Library
The mammalian p38 mitogen‐activated protein kinases (MAPKs) family is composed of four
members (p38α, p38β, p38γ, and p38δ), which are very similar in amino acid sequence but …
members (p38α, p38β, p38γ, and p38δ), which are very similar in amino acid sequence but …